In a systematic review of 48 randomized controlled trials, European researchers found that a single type of exercise—either aerobic, resistance, or performance—was more effective for treating knee osteoarthritis than a mix of different exercise types. For pain reduction, quadriceps-specific resistance exercises were the most efficacious. The study, in the March 2014 Arthritis & Rheumatology, also concluded that the best results were achieved when the exercise program was supervised and engaged in thrice weekly for at least four weeks.