Sometimes the most talented, skilled physicians with whom you work are also prone to displaying challenging behaviors. Often, these physicians are not cognizant of how their colleagues perceive them. So how can you—as the supervisor, friend, and/or peer of such clinicians—help ensure that patients continue to benefit from their clinical and surgical gifts without behavioral difficulties diminishing their contributions?
On Thursday, October 26, 2017 at 8:00 pm EDT, the American Orthopaedic Association (AOA) and The Journal of Bone & Joint Surgery (JBJS) will host a complimentary webinar that will deliver practical and effective methods you can use to help physicians who are clinically outstanding, but behaviorally difficult, start to make remedial changes.
The presentations about how to be helpful to such colleagues will be led by:
- Gerald Hickson, senior VP for Quality,Safety, and Risk Prevention at Vanderbilt University Medical Center
- William Hopkinson, professor of orthopaedic surgery at Loyola Medicine
- George Russell, professor and chair of orthopaedic traumatology at the University of Mississippi Medical Center
Moderated by Dr. Douglas Lundy, orthopaedic trauma surgeon at Resurgens Orthopaedics, this webinar will include a 15-minute live Q&A session during which attendees can ask questions of the panelists.
Seats are limited, so register now!
Minimizing perioperative blood loss during total knee arthroplasty (TKA) helps curtail the risks and costs of allogeneic blood transfusions. Currently, the most popular pharmacological approach to blood conservation is the antifibrinolytic agent tranexamic acid (TXA). But in a randomized trial published in the October 4, 2017 edition of The Journal of Bone & Joint Surgery, Boese et al. found that a similar and much less expensive compound, epsilon-aminocaproic acid (EACA), performed almost as effectively and just as safely as TXA in patients undergoing unilateral knee replacement.
Although the 98 patients in the study who received TXA averaged less estimated blood loss than the 96 patients who received EACA, no transfusions were required in either group, and there were no statistically significant or clinically relevant between-group differences in the change in hemoglobin levels. On the safety/complication side, there were no statistically significant between-group differences in any measured parameter, including postoperative serum creatinine levels or renal, bleeding, or thrombotic complications. However, there were 3 pulmonary emboli in the EACA group compared with only 1 in the TXA group. While that was not a statistically significant difference, “an observed difference of this magnitude could limit the usefulness of EACA in TKA,” the authors caution.
This study did not compare the current cost of the two compounds, but back in 2012, when the authors’ institution added antifibrinolytics to their blood management program, TXA cost $43/g, compared with $0.20/g for EACA. The cost differential is striking, even when you consider that TXA is at least 7 times more potent than EACA on a molar basis, so less of the former drug is required.
Boese et al. conclude that “TXA does not have superior blood conservation effects or safety profile compared with EACA in TKA,” but they cite a need for future equivalence, superiority, and noninferiority trials with these drugs.