An Efficient Way to Find Bone-making Cells in Fat Tissue

Brown University scientists have found a more efficient way to identify potential bone-producing cells from human fat tissue, according to a new study in Stem Cell Research & Therapy. The researchers developed a fluorescent tag that latches onto cells that express a gene called ALPL, which is an indicator of increased osteogenic potential. A machine then detects the fluorescing light and separates the ALPL cells. According to the study, this new method produces more than twice the yield of bone-making cells (9 percent) compared to previous methods of sorting based on cell-surface proteins. Researchers found that the ALPL-positive cells also showed increases in metabolite production for chondrogenesis.

Hetal Marble, lead author of the study, said in a Brown University press release that targeting gene expression rather than surface proteins in the search for cells capable of making new tissue is a “paradigm shift” that “allow[s] us to isolate cells that are capable of doing what we want.” To read the full press release, click here:

To read the Stem Cell Research & Therapy study, click here:

Tags: , , , , , , ,

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: